A Surprising Link Between Work and Male Fertility

Male fertility is a subject of growing concern in the modern world, with factors such as lifestyle, environmental exposures, and dietary choices being widely discussed. However, a recent study has shed light on a lesser-explored area of male fertility: occupational factors. Researchers from the Environment and Reproductive Health (EARTH) study have conducted an investigation to determine if occupational factors have any association with markers of testicular function among men seeking infertility treatment at a fertility center. In this article, we’ll delve into the key findings of this study and their implications for both individuals curious about male fertility and healthcare professionals involved in reproductive medicine.

Understanding the Study

The research, led by Mínguez-Alarcón et al., involved 377 men who were male partners in couples seeking infertility treatment at a fertility center. These men were enrolled in the EARTH study between 2005 and 2019. The study collected self-reported information on various occupational factors, such as lifting and moving heavy objects, the nature of work shifts, and the level of physical exertion at work. In addition, semen samples were analyzed in accordance with World Health Organization guidelines, and reproductive hormone concentrations were assessed using enzyme immunoassays. The study aimed to evaluate the relationship between these occupational factors and markers of testicular function, while adjusting for several covariates such as age, BMI, education, race, smoking, and abstinence time.

Key Findings

The findings of this study provided intriguing insights into the impact of occupational factors on male fertility:

  1. Higher Sperm Concentration and Total Sperm Count: Men involved in occupations that required often lifting or moving heavy objects at work had 46% higher sperm concentrations and 44% higher total sperm counts compared to those who reported never lifting heavy objects at work.
  2. Shift Work Matters: Men working in evening or rotating shifts exhibited a 24% higher testosterone concentration and a 45% higher estradiol concentration compared to those working day shifts.
  3. Physical Exertion: Men engaged in physically demanding jobs with heavy or moderate levels of physical exertion had higher circulating testosterone concentrations compared to those with lighter exertion.
  4. Hormonal Balance: Men involved in lifting or moving heavy objects at work had higher estradiol concentrations compared to those who never did.

It’s important to note that no significant associations were found between these occupational factors and other markers of testicular function, such as ejaculated volume, total motility, morphologically normal sperm, or serum FSH and LH concentrations.


These findings have significant implications for both individuals interested in male fertility and healthcare professionals in the field of reproductive medicine:

  • Public Health Significance: Male fertility is not only crucial for reproduction but also has broader implications for public health. This study underscores the importance of considering occupational factors in discussions about male fertility and overall well-being.
  • Fertility Clinics: Healthcare professionals working in fertility clinics should be aware of the potential impact of occupational factors on male fertility. This knowledge can help tailor treatment plans and advice for couples seeking infertility treatment.
  • Further Research: While these findings are promising, more research is needed to confirm the associations observed in this study. Future investigations in broader populations could provide a clearer picture of how various occupational factors affect male fertility.


In the realm of male fertility, occupational factors are emerging as an important area of study. The recent research led by Mínguez-Alarcón et al. highlights the potential impact of occupations involving heavy lifting, physically demanding tasks, and non-standard work shifts on male reproductive health. As our understanding of these factors deepens, it can lead to more personalized approaches to male infertility treatment and promote overall well-being among men seeking to start a family.

BMI: body mass index; FSH: follicle-stimulating hormone; LH: luteinizing hormone

Reference: Mínguez-Alarcón L, Williams PL, Souter I, et al. Occupational factors and markers of testicular function among men attending a fertility center. Hum Reprod. 2023;38(4):529-536. doi:10.1093/humrep/dead027

Link to the research article: https://pubmed.ncbi.nlm.nih.gov/36772979/

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